| Round 1 | |||||
| 6 March | South Sydney Rabbitohs | 34 – 32 | Sydney Roosters | ANZ Stadium | View |
| 7 March | Canterbury Bulldogs | 24 – 30 | Brisbane Broncos | ANZ Stadium | View |
| 8 March | Penrith Panthers | 22 – 34 | Newcastle Knights | Sportingbet Stadium | View |
| 8 March | Manly Sea Eagles | 34 – 20 | Melbourne Storm | Brookvale Oval | View |
| 8 March | North Queensland Cowboys | 42 – 26 | Canberra Raiders | 1300SMILES Stadium | View |
| 9 March | St George Illawarra Dragons | 46 – 16 | Wests Tigers | ANZ Stadium | View |
| 9 March | Parramatta Eels | 50 – 24 | Warriors | Pirtek Stadium | View |
| 10 March | Cronulla Sharks | 50 – 22 | Gold Coast Titans | Remondis Stadium | View |
| Round 2 | |||||
| 14 March | Manly Sea Eagles | 16 – 30 | South Sydney Rabbitohs | Central Coast Stadium | View |
| 14 March | Brisbane Broncos | 38 – 22 | North Queensland Cowboys | Suncorp Stadium | View |
| 15 March | Warriors | 16 – 40 | St George Illawarra Dragons | Eden Park | View |
| 15 March | Melbourne Storm | 42 – 24 | Penrith Panthers | AAMI Park | View |
| 15 March | Sydney Roosters | 24 – 16 | Parramatta Eels | Allianz Stadium | View |
| 16 March | Gold Coast Titans | 4 – 34 | Wests Tigers | Cbus Super Stadium | View |
| 16 March | Newcastle Knights | 34 – 28 | Canberra Raiders | Hunter Stadium | View |
| 17 March | Canterbury Bulldogs | 30 – 32 | Cronulla Sharks | ANZ Stadium | View |
| Round 3 | |||||
| 21 March | Wests Tigers | 26 – 16 | South Sydney Rabbitohs | ANZ Stadium | View |
| 21 March | Brisbane Broncos | 44 – 14 | Sydney Roosters | Suncorp Stadium | View |
| 22 March | Penrith Panthers | 14 – 34 | Canterbury Bulldogs | Sportingbet Stadium | View |
| 22 March | Cronulla Sharks | 28 – 32 | St George Illawarra Dragons | Remondis Stadium | View |
| 22 March | North Queensland Cowboys | 12 – 50 | Warriors | 1300SMILES Stadium | View |
| 23 March | Manly Sea Eagles | 20 – 48 | Parramatta Eels | Brookvale Oval | View |
| 23 March | Canberra Raiders | 44 – 22 | Gold Coast Titans | GIO Stadium | View |
| 24 March | Melbourne Storm | 0 – 50 | Newcastle Knights | AAMI Park | View |
| Round 4 | |||||
| 28 March | St George Illawarra Dragons | 44 – 14 | Brisbane Broncos | WIN Stadium | View |
| 29 March | Sydney Roosters | 46 – 24 | Manly Sea Eagles | St Marys Leagues Stadium | View |
| 29 March | Warriors | 26- 24 | Wests Tigers | Westpac Stadium | View |
| 29 March | Parramatta Eels | 26 – 18 | Penrith Panthers | Pirtek Stadium | View |
| 30 March | Newcastle Knights | 56 – 10 | Cronulla Sharks | Hunter Stadium | View |
| 30 March | South Sydney Rabbitohs | 30 – 34 | Canberra Raiders | ANZ Stadium | View |
| 30 March | Canterbury Bulldogs | 24 – 40 | Melbourne Storm | Lidcombe Oval | View |
| 31 March | Gold Coast Titans | 34 – 36 | North Queensland Cowboys | Cbus Super Stadium | View |
| Round 5 | |||||
| 4 April | Sydney Roosters | 44 – 12 | Canterbury Bulldogs | Allianz Stadium | View |
| 4 April | Brisbane Broncos | 24 – 28 | Parramatta Eels | Suncorp Stadium | View |
| 5 April | Cronulla Sharks | 32 – 26 | Warriors | Remondis Stadium | View |
| 5 April | Penrith Panthers | 42 – 12 | Canberra Raiders | Sportingbet Stadium | View |
| 5 April | St George Illawarra Dragons | 36 – 4 | South Sydney Rabbitohs | Sydney Cricket Ground | View |
| 6 April | Melbourne Storm | 22 – 50 | Gold Coast Titans | AAMI Park | View |
| 6 April | Wests Tigers | 36 – 16 | Manly Sea Eagles | Leichhardt Oval | View |
| 7 April | North Queensland Cowboys | 16 – 32 | Newcastle Knights | 1300SMILES Stadium | View |
| Round 6 | |||||
| 11 April | Penrith Panthers | 26 – 10 | South Sydney Rabbitohs | Sportingbet Stadium | View |
| 11 April | Gold Coast Titans | 18 – 34 | Brisbane Broncos | Cbus Super Stadium | View |
| 12 April | Canberra Raiders | 28 – 48 | Newcastle Knights | GIO Stadium | View |
| 12 April | Parramatta Eels | 34 – 46 | Sydney Roosters | Pirtek Stadium | View |
| 12 April | Wests Tigers | 38 – 24 | North Queensland Cowboys | Campbelltown Stadium | View |
| 13 April | Warriors | 58 – 20 | Canterbury Bulldogs | Eden Park | View |
| 13 April | Manly Sea Eagles | 36 – 32 | Cronulla Sharks | Brookvale Oval | View |
| 14 April | Melbourne Storm | 24 – 8 | St George Illawarra Dragons | AAMI Park | View |
| Round 7 | |||||
| 18 April | South Sydney Rabbitohs | 34 – 26 | Canterbury Bulldogs | ANZ Stadium | View |
| 18 April | Newcastle Knights | 34 – 34 | Brisbane Broncos | Hunter Stadium | View |
| 18 April | Manly Sea Eagles | 16 – 30 | North Queensland Cowboys | Central Coast Stadium | View |
| 19 April | St George Illawarra Dragons | 12 – 36 | Warriors | WIN Jubilee Oval | View |
| 19 April | Cronulla Sharks | 24 – 44 | Sydney Roosters | Remondis Stadium | View |
| 20 April | Canberra Raiders | 28 – 22 | Melbourne Storm | GIO Stadium | View |
| 21 April | Parramatta Eels | 58 – 20 | Wests Tigers | ANZ Stadium | View |
| 21 April | Penrith Panthers | 26 – 6 | Gold Coast Titans | Sportingbet Stadium | View |
| Round 8 | |||||
| 25 April | St George Illawarra Dragons | 24 – 22 | Sydney Roosters | Allianz Stadium | View |
| 25 April | Melbourne Storm | 36 – 14 | Warriors | AAMI Park | View |
| 25 April | Brisbane Broncos | 20 – 12 | South Sydney Rabbitohs | Suncorp Stadium | View |
| 26 April | Cronulla Sharks | 20 – 32 | Penrith Panthers | Remondis Stadium | View |
| 26 April | North Queensland Cowboys | 4 – 64 | Parramatta Eels | 1300SMILES Stadium | View |
| 26 April | Canterbury Bulldogs | 18 – 30 | Newcastle Knights | ANZ Stadium | View |
| 27 April | Manly Sea Eagles | 24 – 34 | Canberra Raiders | Brookvale Oval | View |
| 27 April | Wests Tigers | 14 – 36 | Gold Coast Titans | Leichhardt Oval | View |
| Round 9 | |||||
| 9 May | Sydney Roosters | 18 – 22 | Wests Tigers | Allianz Stadium | View |
| 9 May | North Queensland Cowboys | 16 – 24 | Brisbane Broncos | 1300SMILES Stadium | View |
| 10 May | Warriors | 54 – 0 | Canberra Raiders | Eden Park | View |
| 10 May | Gold Coast Titans | 14 – 24 | South Sydney Rabbitohs | Cbus Super Stadium | View |
| 10 May | Melbourne Storm | 28 – 14 | Manly Sea Eagles | AAMI Park | View |
| 11 May | Newcastle Knights | 40 – 22 | Penrith Panthers | Hunter Stadium | View |
| 11 May | St George Illawarra Dragons | 50 – 10 | Canterbury Bulldogs | ANZ Stadium | View |
| 12 May | Parramatta Eels | 38 – 34 | Cronulla Sharks | Pirtek Stadium | View |
| Round 10 | |||||
| 16 May | South Sydney Rabbitohs | 36 – 8 | Melbourne Storm | ANZ Stadium | View |
| 16 May | Brisbane Broncos | 28 – 20 | Gold Coast Titans | Suncorp Stadium | View |
| 17 May | Parramatta Eels | 32 – 30 | St George Illawarra Dragons | Pirtek Stadium | View |
| 17 May | Cronulla Sharks | 24 – 34 | Wests Tigers | Remondis Stadium | View |
| 17 May | North Queensland Cowboys | 14 – 55 | Sydney Roosters | 1300SMILES Stadium | View |
| 18 May | Canberra Raiders | 34 – 16 | Penrith Panthers | GIO Stadium | View |
| 18 May | Canterbury Bulldogs | 31 – 30 | Warriors | Waikato Stadium | View |
| 19 May | Manly Sea Eagles | 40 – 38 | Newcastle Knights | Brookvale Oval | View |
| Round 11 | |||||
| 23 May | Canterbury Bulldogs | 12 – 22 | Sydney Roosters | ANZ Stadium | View |
| 24 May | Gold Coast Titans | 16 – 20 | Warriors | Cbus Super Stadium | View |
| 24 May | Wests Tigers | 42 – 10 | Brisbane Broncos | Campbelltown Stadium | View |
| 25 May | Canberra Raiders | 30 – 44 | North Queensland Cowboys | GIO Stadium | View |
| 26 May | Cronulla Sharks | 26 – 28 | South Sydney Rabbitohs | Remondis Stadium | View |
| Manly Sea Eagles | BYE | ||||
| Melbourne Storm | BYE | ||||
| Newcastle Knights | BYE | ||||
| Parramatta Eels | BYE | ||||
| Penrith Panthers | BYE | ||||
| St George Illawarra Dragons | BYE |
| Round 12 | |||||
| 30 May | Penrith Panthers | 18 – 14 | Parramatta Eels | Sportingbet Stadium | View |
| 31 May | Sydney Roosters | 30 – 29 | Canberra Raiders | Allianz Stadium | View |
| 31 May | North Queensland Cowboys | 22 – 20 | Melbourne Storm | 1300SMILES Stadium | View |
| 1 June | Warriors | 34 – 22 | Newcastle Knights | Mt Smart Stadium | View |
| 1 June | Brisbane Broncos | 42 – 24 | Manly Sea Eagles | Suncorp Stadium | View |
| 2 June | South Sydney Rabbitohs | 24 – 36 | St George Illawarra Dragons | ANZ Stadium | View |
| Canterbury Bulldogs | BYE | ||||
| Cronulla Sharks | BYE | ||||
| Gold Coast Titans | BYE | ||||
| Wests Tigers | BYE |
| Round 13 | |||||
| 6 June | Manly Sea Eagles | 28 – 12 | Canterbury Bulldogs | Brookvale Oval | View |
| 6 June | Parramatta Eels | 48 – 22 | North Queensland Cowboys | Pirtek Stadium | View |
| 7 June | Gold Coast Titans | 18 – 34 | Penrith Panthers | Cbus Super Stadium | View |
| 7 June | St George Illawarra Dragons | 32 – 18 | Cronulla Sharks | WIN Stadium | View |
| 7 June | South Sydney Rabbitohs | 28 – 26 | Warriors | Redfern Oval | View |
| 8 June | Newcastle Knights | 22 – 28 | Wests Tigers | Hunter Stadium | View |
| 8 June | Melbourne Storm | 14 – 34 | Sydney Roosters | AAMI Park | View |
| 9 June | Canberra Raiders | 28 – 34 | Brisbane Broncos | GIO Stadium | View |
| Round 14 | |||||
| June 13 | South Sydney Rabbitohs | 18 – 28 | Wests Tigers | ANZ Stadium | View |
| June 14 | Penrith Panthers | 26 – 6 | St George Illawarra Dragons | Sportingbet Stadium | View |
| June 14 | Sydney Roosters | 24 – 28 | Newcastle Knights | Allianz Stadium | View |
| June 15 | Canterbury Bulldogs | 26 – 28 | Parramatta Eels | ANZ Stadium | View |
| June 16 | Gold Coast Titans | 10 – 34 | Melbourne Storm | Cbus Super Stadium | View |
| Brisbane Broncos | BYE | ||||
| Canberra Raiders | BYE | ||||
| Cronulla Sharks | BYE | ||||
| Manly Sea Eagles | BYE | ||||
| North Queensland Cowboys | BYE | ||||
| Warriors | BYE |
| Round 15 | |||||
| June 20 | Canberra Raiders | 44 – 26 | Canterbury Bulldogs | GIO Stadium | View |
| June 21 | Warriors | 18 – 36 | Brisbane Broncos | Mt Smart Stadium | View |
| June 21 | Cronulla Sharks | 22 – 22 | Manly Sea Eagles | Remondis Stadium | View |
| June 22 | Melbourne Storm | 26 – 22 | Parramatta Eels | AAMI Park | View |
| June 22 | Gold Coast Titans | 16 – 44 | St George Illawarra Dragons | Cbus Super Stadium | View |
| June 23 | Newcastle Knights | 64 – 16 | North Queensland Cowboys | Hunter Stadium | View |
| Penrith Panthers | BYE | ||||
| South Sydney Rabbitohs | BYE | ||||
| Sydney Roosters | BYE | ||||
| Wests Tigers | BYE |
| Round 16 | |||||
| June 27 | Manly Sea Eagles | 32 – 24 | Sydney Roosters | Brookvale Oval | View |
| June 27 | Brisbane Broncos | 32 – 10 | Cronulla Sharks | Suncorp Stadium | View |
| June 28 | Wests Tigers | 46 – 16 | Canberra Raiders | Campbelltown Stadium | View |
| June 28 | North Queensland Cowboys | 18 – 28 | South Sydney Rabbitohs | 1300SMILES Stadium | View |
| June 29 | Warriors | 30 – 13 | Penrith Panthers | Mt Smart Stadium | View |
| June 29 | Parramatta Eels | 16 – 20 | Newcastle Knights | Pirtek Stadium | View |
| June 30 | St George Illawarra Dragons | 6 – 26 | Melbourne Storm | WIN Stadium | View |
| Canterbury Bulldogs | BYE | ||||
| Gold Coast Titans | BYE |
| Round 17 | |||||
| July 4 | Canterbury Bulldogs | 14 – 34 | Manly Sea Eagles | ANZ Stadium | View |
| July 5 | St George Illawarra Dragons | 30 – 20 | North Queensland Cowboys | WIN Jubilee Oval | View |
| July 5 | Sydney Roosters | 34 – 16 | Cronulla Sharks | Allianz Stadium | View |
| July 6 | Wests Tigers | 30 – 18 | Penrith Panthers | Leichhardt Oval | View |
| July 7 | South Sydney Rabbitohs | 16 – 36 | Gold Coast Titans | ANZ Stadium | View |
| Brisbane Broncos | BYE | ||||
| Canberra Raiders | BYE | ||||
| Melbourne Storm | BYE | ||||
| Newcastle Knights | BYE | ||||
| Parramatta Eels | BYE | ||||
| Warriors | BYE |
| Round 18 | |||||
| July 11 | Manly Sea Eagles | 40 – 32 | Wests Tigers | Brookvale Oval | View |
| July 12 | Warriors | 19 – 22 | Parramatta Eels | Mt Smart Stadium | View |
| July 12 | Melbourne Storm | 22 – 20 | Canterbury Bulldogs | AAMI Park | View |
| July 13 | Gold Coast Titans | 60 – 22 | Canberra Raiders | Cbus Super Stadium | View |
| July 13 | Cronulla Sharks | 22 – 22 | Newcastle Knights | Remondis Stadium | View |
| July 14 | Penrith Panthers | 50 – 18 | Brisbane Broncos | Sportingbet Stadium | View |
| North Queensland Cowboys | BYE | ||||
| St George Illawarra Dragons | BYE | ||||
| South Sydney Rabbitohs | BYE | ||||
| Sydney Roosters | BYE |
| Round 19 | |||||
| July 18 | Cronulla Sharks | 24 – 22 | North Queensland Cowboys | Remondis Stadium | View |
| July 18 | Parramatta Eels | 40 – 26 | South Sydney Rabbitohs | Pirtek Stadium | View |
| July 19 | Sydney Roosters | 32 – 18 | Penrith Panthers | Allianz Stadium | View |
| July 19 | Melbourne Storm | 54 – 10 | Canberra Raiders | AAMI Park | View |
| July 19 | Brisbane Broncos | 18 – 40 | Warriors | Suncorp Stadium | View |
| July 20 | Newcastle Knights | 42 – 12 | Gold Coast Titans | Hunter Stadium | View |
| July 20 | Wests Tigers | 42 – 10 | Canterbury Bulldogs | ANZ Stadium | View |
| July 21 | St George Illawarra Dragons | 16 – 18 | Manly Sea Eagles | WIN Jubilee Oval | View |
| Round 20 | |||||
| July 25 | Newcastle Knights | 16 – 40 | Sydney Roosters | Hunter Stadium | View |
| July 25 | Brisbane Broncos | 14 – 16 | Melbourne Storm | Suncorp Stadium | View |
| July 26 | Penrith Panthers | 18 – 14 | Cronulla Sharks | Carrington Park | View |
| July 26 | Gold Coast Titans | 36 – 26 | Parramatta Eels | Cbus Super Stadium | View |
| July 26 | Canterbury Bulldogs | 20 – 46 | North Queensland Cowboys | ANZ Stadium | View |
| July 27 | Warriors | 20 – 36 | Manly Sea Eagles | Mt Smart Stadium | View |
| July 27 | Wests Tigers | 26 – 28 | St George Illawarra Dragons | ANZ Stadium | View |
| July 28 | Canberra Raiders | 18 – 22 | South Sydney Rabbitohs | GIO Stadium | View |
| Round 21 | |||||
| August 1 | Manly Sea Eagles | 34 – 44 | Brisbane Broncos | Brookvale Oval | View |
| August 1 | Canterbury Bulldogs | 30 – 54 | Penrith Panthers | ANZ Stadium | View |
| August 2 | Cronulla Sharks | 23 – 34 | Parramatta Eels | Remondis Stadium | View |
| August 2 | Wests Tigers | 24 – 22 | Melbourne Storm | Campbelltown Stadium | View |
| August 2 | South Sydney Rabbitohs | 18 – 32 | Newcastle Knights | Redfern Oval | View |
| August 2 | North Queensland Cowboys | 31 – 30 | Gold Coast Titans | 1300SMILES Stadium | View |
| August 2 | Sydney Roosters | 20 – 22 | St George Illawarra Dragons | Allianz Stadium | View |
| August 3 | Canberra Raiders | 6 – 54 | Warriors | GIO Stadium | View |
| Round 22 | |||||
| August 8 | South Sydney Rabbitohs | 28 – 14 | Manly Sea Eagles | Sydney Cricket Ground | View |
| August 8 | Brisbane Broncos | 28 – 18 | Canterbury Bulldogs | Suncorp Stadium | View |
| August 9 | Newcastle Knights | 38 – 0 | Melbourne Storm | Hunter Stadium | View |
| August 9 | North Queensland Cowboys | 30 – 16 | Wests Tigers | 1300SMILES Stadium | View |
| August 10 | Warriors | 40 – 0 | Cronulla Sharks | Mt Smart Stadium | View |
| August 10 | St George Illawarra Dragons | 18 – 26 | Penrith Panthers | WIN Stadium | View |
| August 10 | Parramatta Eels | 54 – 26 | Canberra Raiders | Ringrose Park | View |
| August 11 | Sydney Roosters | 46 – 16 | Gold Coast Titans | Allianz Stadium | View |
| Round 23 | |||||
| August 16 | Canberra Raiders | 22 – 42 | St George Illawarra Dragons | GIO Stadium | View |
| August 16 | South Sydney Rabbitohs | 32 – 36 | Brisbane Broncos | Redfern Oval | View |
| August 16 | Melbourne Storm | 10 – 20 | Cronulla Sharks | AAMI Park | View |
| August 16 | Wests Tigers | 28 – 28 | Sydney Roosters | Leichhardt Oval | View |
| August 17 | Newcastle Knights | 40 – 34 | Warriors | Hunter Stadium | View |
| August 17 | Gold Coast Titans | 62 – 22 | Manly Sea Eagles | Cbus Super Stadium | View |
| August 17 | Parramatta Eels | 24 – 22 | Canterbury Bulldogs | Ringrose Park | View |
| August 18 | Penrith Panthers | 38 – 16 | North Queensland Cowboys | Sportingbet Stadium | View |
| Round 24 | |||||
| August 21 | Canterbury Bulldogs | 22 – 24 | Wests Tigers | ANZ Stadium | View |
| August 22 | Parramatta Eels | 10 – 24 | Manly Sea Eagles | Pirtek Stadium | View |
| August 23 | Brisbane Broncos | 36 – 16 | Newcastle Knights | Suncorp Stadium | View |
| August 23 | South Sydney Rabbitohs | 16 – 4 | North Queensland Cowboys | ANZ Stadium | View |
| August 24 | Warriors | 18 – 20 | Sydney Roosters | Mt Smart Stadium | View |
| August 24 | Cronulla Sharks | 16 – 38 | Canberra Raiders | Remondis Stadium | View |
| August 24 | St George Illawarra Dragons | 42 – 16 | Gold Coast Titans | WIN Jubilee Oval | View |
| August 25 | Penrith Panthers | 20 – 22 | Melbourne Storm | Sportingbet Stadium | View |
| Round 25 | |||||
| August 29 | Brisbane Broncos | 18 – 58 | St George Illawarra Dragons | Suncorp Stadium | View |
| August 30 | Newcastle Knights | 34 – 30 | Parramatta Eels | Hunter Stadium | View |
| August 30 | Canterbury Bulldogs | 24 – 36 | South Sydney Rabbitohs | Campbelltown Stadium | View |
| August 30 | Canberra Raiders | 28 – 24 | Wests Tigers | GIO Stadium | View |
| August 30 | Sydney Roosters | 36 – 24 | Melbourne Storm | Campbelltown Stadium | View |
| August 30 | North Queensland Cowboys | 16 – 18 | Cronulla Sharks | Jack Manski Oval | View |
| August 31 | Warriors | 28 – 12 | Gold Coast Titans | Mt Smart Stadium | View |
| August 31 | Manly Sea Eagles | 28 – 24 | Penrith Panthers | Brookvale Oval | View |
| Round 26 | |||||
| September 4 | Sydney Roosters | 22 – 24 | South Sydney Rabbitohs | Allianz Stadium | View |
| September 5 | Melbourne Storm | 0 – 32 | Brisbane Broncos | AAMI Park | View |
| September 6 | Wests Tigers | 30 – 10 | Cronulla Sharks | Leichhardt Oval | View |
| September 6 | Canberra Raiders | 10 – 50 | Parramatta Eels | GIO Stadium | View |
| September 6 | North Queensland Cowboys | 24 – 36 | Manly Sea Eagles | 1300SMILES Stadium | View |
| September 7 | Newcastle Knights | 36 – 26 | St George Illawarra Dragons | Hunter Stadium | View |
| September 7 | Gold Coast Titans | 18 – 38 | Canterbury Bulldogs | Cbus Super Stadium | View |
| September 7 | Penrith Panthers | 18 – 18 | Warriors | Sportingbet Stadium | View |