| Round 1 | |||||
| 5 March | Brisbane Broncos | 36 – 10 | South Sydney Rabbitohs | Suncorp Stadium | View |
| 6 March | Parramatta Eels | 26 – 54 | Manly Sea Eagles | Pirtek Stadium | View |
| 7 March | Newcastle Knights | 41 – 16 | Warriors | Hunter Stadium | View |
| 7 March | Gold Coast Titans | 34 – 16 | Wests Tigers | Cbus Super Stadium | View |
| 7 March | North Queensland Cowboys | 53 – 14 | Sydney Roosters | 1300SMILES Stadium | View |
| 8 March | Penrith Panthers | 30 – 12 | Canterbury Bulldogs | Pepper Stadium | View |
| 8 March | Cronulla Sharks | 32 – 34 | Canberra Raiders | Remondis Stadium | View |
| 9 March | St George Illawarra Dragons | 8 – 34 | Melbourne Storm | Jubilee Oval | View |
| Round 2 | |||||
| 13 March | Canterbury Bulldogs | 10 – 30 | Parramatta Eels | ANZ Stadium | View |
| 13 March | Cronulla Sharks | 22 – 36 | Brisbane Broncos | Remondis Stadium | View |
| 14 March | Penrith Panthers | 26 – 36 | Gold Coast Titans | Carrington Park | View |
| 14 March | Manly Sea Eagles | 46 – 20 | Melbourne Storm | Brookvale Oval | View |
| 14 March | North Queensland Cowboys | 42 – 22 | Newcastle Knights | 1300SMILES Stadium | View |
| 15 March | South Sydney Rabbitohs | 24 – 22 | Sydney Roosters | ANZ Stadium | View |
| 15 March | Canberra Raiders | 24 – 44 | Warriors | GIO Stadium | View |
| 16 March | Wests Tigers | 50 – 26 | St George Illawarra Dragons | Campbelltown Stadium | View |
| Round 3 | |||||
| 20 March | Manly Sea Eagles | 34 – 16 | Canterbury Bulldogs | Brookvale Oval | View |
| 20 March | Brisbane Broncos | 30 – 26 | North Queensland Cowboys | Suncorp Stadium | View |
| 21 March | Warriors | 10 – 38 | Parramatta Eels | Mt Smart Stadium | View |
| 21 March | Canberra Raiders | 60 – 10 | St George Illawarra Dragons | GIO Stadium | View |
| 21 March | Melbourne Storm | 44 – 12 | Cronulla Sharks | AAMI Park | View |
| 22 March | South Sydney Rabbitohs | 24 – 20 | Wests Tigers | ANZ Stadium | View |
| 22 March | Gold Coast Titans | 18 – 19 | Newcastle Knights | Cbus Super Stadium | View |
| 23 March | Sydney Roosters | 18 – 28 | Penrith Panthers | Allianz Stadium | View |
| Round 4 | |||||
| 27 March | Parramatta Eels | 28 – 26 | South Sydney Rabbitohs | Pirtek Stadium | View |
| 27 March | Wests Tigers | 34 – 22 | Canterbury Bulldogs | ANZ Stadium | View |
| 28 March | Newcastle Knights | 34 – 8 | Penrith Panthers | Hunter Stadium | View |
| 28 March | Cronulla Sharks | 30 – 12 | Gold Coast Titans | Remondis Stadium | View |
| 28 March | North Queensland Cowboys | 50 – 6 | Melbourne Storm | Jack Manski Oval | View |
| 28 March | St George Illawarra Dragons | 22 – 24 | Manly Sea Eagles | WIN Stadium | View |
| 29 March | Warriors | 40 – 14 | Brisbane Broncos | Mt Smart Stadium | View |
| 29 March | Sydney Roosters | 46 – 16 | Canberra Raiders | Allianz Stadium | View |
| Round 5 | |||||
| 3 April | Canterbury Bulldogs | 20 – 18 | South Sydney Rabbitohs | ANZ Stadium | View |
| 3 April | Gold Coast Titans | 18 – 44 | Brisbane Broncos | Cbus Super Stadium | View |
| 4 April | Newcastle Knights | 36 – 46 | St George Illawarra Dragons | Hunter Stadium | View |
| 5 April | Manly Sea Eagles | 36 – 22 | Canberra Raiders | Central Coast Stadium | View |
| 5 April | Sydney Roosters | 68 – 6 | Cronulla Sharks | Allianz Stadium | View |
| 6 April | Parramatta Eels | 12 – 40 | Wests Tigers | ANZ Stadium | View |
| 6 April | Melbourne Storm | 38 – 28 | Warriors | AAMI Park | View |
| 6 April | Penrith Panthers | 32 – 22 | North Queensland Cowboys | Pepper Stadium | View |
| Round 6 | |||||
| 10 April | Brisbane Broncos | 48 – 6 | Sydney Roosters | Suncorp Stadium | View |
| 10 April | Cronulla Sharks | 18 – 22 | Newcastle Knights | Remondis Stadium | View |
| 11 April | Parramatta Eels | 22 – 40 | Gold Coast Titans | Pirtek Stadium | View |
| 11 April | Warriors | 38 – 4 | Wests Tigers | Mt Smart Stadium | View |
| 11 April | Penrith Panthers | 36 – 16 | Manly Sea Eagles | Pepper Stadium | View |
| 12 April | Canberra Raiders | 28 – 24 | Melbourne Storm | GIO Stadium | View |
| 12 April | St George Illawarra Dragons | 12 – 41 | Canterbury Bulldogs | ANZ Stadium | View |
| 13 April | South Sydney Rabbitohs | 24 – 38 | North Queensland Cowboys | ANZ Stadium | View |
| Round 7 | |||||
| 17 April | St George Illawarra Dragons | 20 – 36 | Brisbane Broncos | Jubilee Oval | View |
| 18 April | Canterbury Bulldogs | 30 – 30 | Manly Sea Eagles | Belmore Sports Ground | View |
| 18 April | Gold Coast Titans | 24 – 36 | Penrith Panthers | Cbus Super Stadium | View |
| 18 April | North Queensland Cowboys | 28 – 28 | Warriors | 1300SMILES Stadium | View |
| 18 April | Melbourne Storm | 6 – 54 | Sydney Roosters | AAMI Park | View |
| 19 April | Wests Tigers | 32 – 40 | Canberra Raiders | Leichhardt Oval | View |
| 19 April | Newcastle Knights | 4 – 46 | Parramatta Eels | Hunter Stadium | View |
| 20 April | Cronulla Sharks | 26 – 22 | South Sydney Rabbitohs | Remondis Stadium | View |
| Round 8 | |||||
| 24 April | Canterbury Bulldogs | 6 – 46 | Wests Tigers | ANZ Stadium | View |
| 25 April | Warriors | 34 – 12 | Gold Coast Titans | Mt Smart Stadium | View |
| 25 April | Newcastle Knights | 16 – 56 | North Queensland Cowboys | Hunter Stadium | View |
| 25 April | Sydney Roosters | 50 – 14 | St George Illawarra Dragons | Allianz Stadium | View |
| 25 April | South Sydney Rabbitohs | 36 – 22 | Canberra Raiders | Erskineville Oval | View |
| 25 April | Melbourne Storm | 18 – 12 | Manly Sea Eagles | AAMI Park | View |
| 25 April | Brisbane Broncos | 50 – 28 | Parramatta Eels | Suncorp Stadium | View |
| 26 April | Penrith Panthers | 34 – 4 | Cronulla Sharks | Pepper Stadium | View |
| Round 9 | |||||
| 8 May | Brisbane Broncos | 24 – 40 | Penrith Panthers | Suncorp Stadium | View |
| 8 May | Sydney Roosters | 38 – 28 | Wests Tigers | Allianz Stadium | View |
| 9 May | Canberra Raiders | 46 – 18 | Gold Coast Titans | GIO Stadium | View |
| 9 May | Manly Sea Eagles | 18 – 28 | Newcastle Knights | Henson Park | View |
| 9 May | South Sydney Rabbitohs | 26 – 24 | St George Illawarra Dragons | Redfern Oval | View |
| 9 May | Cronulla Sharks | 23 – 22 | Warriors | Remondis Stadium | View |
| 9 May | North Queensland Cowboys | 42 – 20 | Canterbury Bulldogs | 1300SMILES Stadium | View |
| 10 May | Parramatta Eels | 32 – 34 | Melbourne Storm | Pirtek Stadium | View |
| Round 10 | |||||
| 15 May | North Queensland Cowboys | 10 – 44 | Brisbane Broncos | 1300SMILES Stadium | View |
| 16 May | Parramatta Eels | 16 – 46 | Warriors | Pirtek Stadium | View |
| 16 May | Manly Sea Eagles | 16 – 42 | Penrith Panthers | St Marys Leagues Stadium | View |
| 16 May | Gold Coast Titans | 16 – 18 | Cronulla Sharks | Cbus Super Stadium | View |
| 16 May | Canterbury Bulldogs | 28 – 20 | Sydney Roosters | Belmore Sports Ground | View |
| 16 May | Melbourne Storm | 38 – 26 | South Sydney Rabbitohs | Gosch’s Paddock | View |
| 17 May | St George Illawarra Dragons | 24 – 20 | Canberra Raiders | WIN Stadium | View |
| 17 May | Newcastle Knights | 16 – 52 | Wests Tigers | Hunter Stadium | View |
| Round 11 | |||||
| 22 May | South Sydney Rabbitohs | 26 – 26 | Parramatta Eels | ANZ Stadium | View |
| 23 May | Wests Tigers | 14 – 24 | North Queensland Cowboys | Campbelltown Stadium | View |
| 24 May | Canberra Raiders | 32 – 28 | Canterbury Bulldogs | GIO Stadium | View |
| 25 May | Newcastle Knights | 12 – 52 | Brisbane Broncos | Hunter Stadium | View |
| Cronulla Sharks | BYE | ||||
| Gold Coast Titans | BYE | ||||
| Manly Sea Eagles | BYE | ||||
| Melbourne Storm | BYE | ||||
| Penrith Panthers | BYE | ||||
| St George Illawarra Dragons | BYE | ||||
| Sydney Roosters | BYE | ||||
| Warriors | BYE |
| Round 12 | |||||
| 29 May | Penrith Panthers | 36 – 12 | Parramatta Eels | Pepper Stadium | View |
| 30 May | Gold Coast Titans | 26 – 30 | South Sydney Rabbitohs | Cbus Super Stadium | View |
| 30 May | Canberra Raiders | 48 – 40 | Brisbane Broncos | GIO Stadium | View |
| 30 May | North Queensland Cowboys | 38 – 6 | Manly Sea Eagles | 1300SMILES Stadium | View |
| 31 May | Warriors | 12 – 36 | Newcastle Knights | Mt Smart Stadium | View |
| 31 May | St George Illawarra Dragons | 24 – 30 | Cronulla Sharks | Jubilee Oval | View |
| 1 June | Sydney Roosters | 38 – 29 | Melbourne Storm | Allianz Stadium | View |
| Canterbury Bulldogs | BYE | ||||
| Wests Tigers | BYE |
| Round 13 | |||||
| 5 June | Brisbane Broncos | 28 – 28 | Manly Sea Eagles | Suncorp Stadium | View |
| 5 June | Wests Tigers | 34 – 32 | Gold Coast Titans | Leichhardt Oval | View |
| 6 June | Newcastle Knights | 29 – 28 | Canberra Raiders | Hunter Stadium | View |
| 6 June | South Sydney Rabbitohs | 24 – 34 | Warriors | Redfern Oval | View |
| 6 June | Parramatta Eels | 6 – 54 | North Queensland Cowboys | McCredie Park | View |
| 6 June | Penrith Panthers | 36 – 16 | Melbourne Storm | Pepper Stadium | View |
| 7 June | Cronulla Sharks | 24 – 40 | Sydney Roosters | Remondis Stadium | View |
| 8 June | Canterbury Bulldogs | 31 – 18 | St George Illawarra Dragons | ANZ Stadium | View |
| Round 14 | |||||
| 12 June | Wests Tigers | 28 – 22 | South Sydney Rabbitohs | ANZ Stadium | View |
| 13 June | Warriors | 22 – 38 | Sydney Roosters | Mt Smart Stadium | View |
| 14 June | Gold Coast Titans | 10 – 23 | Canterbury Bulldogs | Cbus Super Stadium | View |
| 15 June | Melbourne Storm | 12 – 48 | Parramatta Eels | AAMI Park | View |
| Brisbane Broncos | BYE | ||||
| Canberra Raiders | BYE | ||||
| Cronulla Sharks | BYE | ||||
| Manly Sea Eagles | BYE | ||||
| Newcastle Knights | BYE | ||||
| North Queensland Cowboys | BYE | ||||
| Penrith Panthers | BYE | ||||
| St George Illawarra Dragons | BYE |
| Round 15 | |||||
| 20 June | Manly Sea Eagles | 44 – 24 | Wests Tigers | Campbelltown Stadium | View |
| 20 June | Canberra Raiders | 16 – 38 | North Queensland Cowboys | GIO Stadium | View |
| 20 June | Gold Coast Titans | 20 – 28 | Warriors | Cbus Super Stadium | View |
| 20 June | Canterbury Bulldogs | 26 – 30 | Penrith Panthers | ANZ Stadium | View |
| 21 June | Newcastle Knights | 10 – 24 | Cronulla Sharks | Hunter Stadium | View |
| 21 June | Melbourne Storm | 6 – 74 | Brisbane Broncos | AAMI Park | View |
| 22 June | St George Illawarra Dragons | 34 – 12 | Sydney Roosters | Allianz Stadium | View |
| Parramatta Eels | BYE | ||||
| South Sydney Rabbitohs | BYE |
| Round 16 | |||||
| 26 June | South Sydney Rabbitohs | 12 – 38 | Manly Sea Eagles | ANZ Stadium | View |
| 26 June | Brisbane Broncos | 40 – 18 | Newcastle Knights | Suncorp Stadium | View |
| 27 June | Warriors | 16 – 24 | Canberra Raiders | Mt Smart Stadium | View |
| 27 June | North Queensland Cowboys | 56 – 10 | Cronulla Sharks | 1300SMILES Stadium | View |
| 27 June | Parramatta Eels | 18 – 8 | St George Illawarra Dragons | Pirtek Stadium | View |
| 28 June | Sydney Roosters | 35 – 40 | Gold Coast Titans | Central Coast Stadium | View |
| 28 June | Wests Tigers | 10 – 6 | Penrith Panthers | Leichhardt Oval | View |
| 29 June | Canterbury Bulldogs | 21 – 20 | Melbourne Storm | Belmore Sports Grounds | View |
| Round 17 | |||||
| 3 July | Penrith Panthers | 22 – 8 | South Sydney Rabbitohs | Pepper Stadium | View |
| 4 July | St George Illawarra Dragons | 24 – 30 | North Queensland Cowboys | WIN Stadium | View |
| 5 July | Manly Sea Eagles | 22 – 22 | Cronulla Sharks | Brookvale Oval | View |
| 6 July | Wests Tigers | 18 – 20 | Parramatta Eels | ANZ Stadium | View |
| Brisbane Broncos | BYE | ||||
| Canberra Raiders | BYE | ||||
| Canterbury Bulldogs | BYE | ||||
| Gold Coast Titans | BYE | ||||
| Melbourne Storm | BYE | ||||
| Newcastle Knights | BYE | ||||
| Sydney Roosters | BYE | ||||
| Warriors | BYE |
| Round 18 | |||||
| 10 July | Canberra Raiders | 24 – 18 | Newcastle Knights | GIO Stadium | View |
| 11 July | Penrith Panthers | 44 – 30 | Sydney Roosters | Pepper Stadium | View |
| 11 July | Canterbury Bulldogs | 14 – 26 | Brisbane Broncos | ANZ Stadium | View |
| 12 July | Warriors | 20 – 24 | Melbourne Storm | Mt Smart Stadium | View |
| 12 July | Gold Coast Titans | 22 – 18 | Manly Sea Eagles | Pizzey Park | View |
| 12 July | Cronulla Sharks | 18 – 26 | St George Illawarra Dragons | Remondis Stadium | View |
| North Queensland Cowboys | BYE | ||||
| Parramatta Eels | BYE | ||||
| South Sydney Rabbitohs | BYE | ||||
| Wests Tigers | BYE |
| Round 19 | |||||
| 17 July | Parramatta Eels | 16 – 16 | Canterbury Bulldogs | ANZ Stadium | View |
| 17 July | Melbourne Storm | 14 – 28 | Penrith Panthers | AAMI Park | View |
| 18 July | Canberra Raiders | 24 – 22 | Cronulla Sharks | GIO Stadium | View |
| 18 July | Manly Sea Eagles | 16 – 34 | North Queensland Cowboys | Brookvale Oval | View |
| 18 July | Newcastle Knights | 38 – 10 | Gold Coast Titans | Hunter Stadium | View |
| 18 July | St George Illawarra Dragons | 26 – 18 | South Sydney Rabbitohs | Allianz Stadium | View |
| 19 July | Sydney Roosters | 20 – 42 | Warriors | Allianz Stadium | View |
| 19 July | Brisbane Broncos | 40 – 24 | Wests Tigers | Suncorp Stadium | View |
| Round 20 | |||||
| 24 July | Wests Tigers | 22 – 28 | Sydney Roosters | ANZ Stadium | View |
| 24 July | Brisbane Broncos | 6 – 36 | Gold Coast Titans | Suncorp Stadium | View |
| 25 July | Warriors | 16 – 36 | Manly Sea Eagles | Mt Smart Stadium | View |
| 25 July | Melbourne Storm | 40 – 18 | St George Illawarra Dragons | Gosch’s Paddock | View |
| 25 July | South Sydney Rabbitohs | 22 – 24 | Newcastle Knights | ANZ Stadium | View |
| 26 July | Penrith Panthers | 64 – 8 | Canberra Raiders | Pepper Stadium | View |
| 26 July | Canterbury Bulldogs | 38 – 10 | Cronulla Sharks | Belmore Sports Ground | View |
| 27 July | North Queensland Cowboys | 50 – 6 | Parramatta Eels | 1300SMILES Stadium | View |
| Round 21 | |||||
| 31 July | Wests Tigers | 34 – 18 | Melbourne Storm | Leichhardt Oval | View |
| 31 July | Sydney Roosters | 30 – 26 | Canterbury Bulldogs | Allianz Stadium | View |
| 1 August | Warriors | 20 – 22 | Cronulla Sharks | Mt Smart Stadium | View |
| 1 August | North Queensland Cowboys | 78 – 12 | Canberra Raiders | 1300SMILES Stadium | View |
| 1 August | Manly Sea Eagles | 22 – 38 | Brisbane Broncos | Central Coast Stadium | View |
| 2 August | St George Illawarra Dragons | 48 – 18 | Newcastle Knights | Jubilee Oval | View |
| 2 August | South Sydney Rabbitohs | 10 – 34 | Penrith Panthers | ANZ Stadium | View |
| 3 August | Gold Coast Titans | 22 – 35 | Parramatta Eels | Cbus Super Stadium | View |
| Round 22 | |||||
| 7 August | Brisbane Broncos | 33 – 30 | Canterbury Bulldogs | Suncorp Stadium | View |
| 7 August | Manly Sea Eagles | 26 – 18 | South Sydney Rabbitohs | Brookvale Oval | View |
| 8 August | Warriors | 26 – 18 | St George Illawarra Dragons | Westpac Stadium | View |
| 8 August | Cronulla Sharks | 22 – 32 | North Queensland Cowboys | Remondis Stadium | View |
| 9 August | Melbourne Storm | 39 – 30 | Gold Coast Titans | AAMI Park | View |
| 9 August | Parramatta Eels | 12 – 36 | Penrith Panthers | Ringrose Park | View |
| 9 August | Newcastle Knights | 24 – 32 | Sydney Roosters | Hunter Stadium | View |
| 10 August | Canberra Raiders | 36 – 34 | Wests Tigers | GIO Stadium | View |
| Round 23 | |||||
| 13 August | North Queensland Cowboys | 44 – 30 | South Sydney Rabbitohs | 1300SMILES Stadium | View |
| 14 August | Brisbane Broncos | 34 – 22 | St George Illawarra Dragons | Suncorp Stadium | View |
| 15 August | Wests Tigers | 54 – 12 | Newcastle Knights | Campbelltown Stadium | View |
| 15 August | Cronulla Sharks | 28 – 28 | Melbourne Storm | Remondis Stadium | View |
| 15 August | Penrith Panthers | 36 – 28 | Warriors | Pepper Stadium | View |
| 15 August | Sydney Roosters | 38 – 26 | Parramatta Eels | Allianz Stadium | View |
| 16 August | Canberra Raiders | 18 – 46 | Manly Sea Eagles | GIO Stadium | View |
| 16 August | Canterbury Bulldogs | 30 – 32 | Gold Coast Titans | Central Coast Stadium | View |
| Round 24 | |||||
| 20 August | St George Illawarra Dragons | 28 – 16 | Penrith Panthers | WIN Stadium | View |
| 21 August | South Sydney Rabbitohs | 24 – 26 | Canterbury Bulldogs | ANZ Stadium | View |
| 22 August | Cronulla Sharks | 20 – 46 | Wests Tigers | Remondis Stadium | View |
| 22 August | Warriors | 10 – 24 | North Queensland Cowboys | Mt Smart Stadium | View |
| 22 August | Sydney Roosters | 16 – 24 | Brisbane Broncos | Allianz Stadium | View |
| 23 August | Gold Coast Titans | 40 – 12 | Canberra Raiders | Cbus Super Stadium | View |
| 23 August | Manly Sea Eagles | 18 – 16 | Parramatta Eels | Brookvale Oval | View |
| 24 August | Melbourne Storm | 18 – 26 | Newcastle Knights | AAMI Park | View |
| Round 25 | |||||
| 27 August | South Sydney Rabbitohs | 26 – 24 | Brisbane Broncos | Allianz Stadium | View |
| 28 August | Manly Sea Eagles | 40 – 16 | Sydney Roosters | Brookvale Oval | View |
| 29 August | Parramatta Eels | 34 – 32 | Cronulla Sharks | Pirtek Stadium | View |
| 29 August | Newcastle Knights | 18 – 52 | Canterbury Bulldogs | Hunter Stadium | View |
| 29 August | Melbourne Storm | 14 – 34 | North Queensland Cowboys | AAMI Park | View |
| 30 August | Wests Tigers | 16 – 16 | Warriors | Campbelltown Stadium | View |
| 30 August | Gold Coast Titans | 18 – 48 | St George Illawarra Dragons | Cbus Super Stadium | View |
| 31 August | Canberra Raiders | 8 – 38 | Penrith Panthers | GIO Stadium | View |
| Round 26 | |||||
| 3 September | Brisbane Broncos | 12 – 48 | Melbourne Storm | Suncorp Stadium | View |
| 4 September | Sydney Roosters | 22 – 22 | South Sydney Rabbitohs | Allianz Stadium | View |
| 5 September | Penrith Panthers | 38 – 16 | Newcastle Knights | Pepper Stadium | View |
| 5 September | St George Illawarra Dragons | 26 – 30 | Wests Tigers | ANZ Stadium | View |
| 5 September | North Queensland Cowboys | 20 – 30 | Gold Coast Titans | 1300SMILES Stadium | View |
| 6 September | Parramatta Eels | 18 – 44 | Canberra Raiders | Pirtek Stadium | View |
| 6 September | Cronulla Sharks | 6 – 52 | Manly Sea Eagles | Remondis Stadium | View |
| 6 September | Canterbury Bulldogs | 14 – 30 | Warriors | ANZ Stadium | View |