| Round 1 | |||||
| 2 March | Cronulla Sharks | 38 – 40 | Brisbane Broncos | S. Cross Group Stadium | View |
| 3 March | Canterbury Bulldogs | 18 – 24 | Melbourne Storm | Belmore Sports Ground | View |
| 3 March | South Sydney Rabbitohs | 28 – 30 | Wests Tigers | ANZ Stadium | View |
| 4 March | St George Illawarra Dragons | 18 – 16 | Penrith Panthers | UOW Jubilee Oval | View |
| 4 March | North Queensland Cowboys | 28 – 12 | Canberra Raiders | 1300SMILES Stadium | View |
| 4 March | Gold Coast Titans | 24 – 38 | Sydney Roosters | Cbus Super Stadium | View |
| 5 March | Warriors | 10 – 48 | Newcastle Knights | Mt Smart Stadium | View |
| 5 March | Manly Sea Eagles | 38 – 20 | Parramatta Eels | Lottoland | View |
| Round 2 | |||||
| 9 March | Sydney Roosters | 34 – 12 | Canterbury Bulldogs | Allianz Stadium | View |
| 10 March | Warriors | 12 – 20 | Melbourne Storm | Mt Smart Stadium | View |
| 10 March | Brisbane Broncos | 18 – 20 | North Queensland Cowboys | Suncorp Stadium | View |
| 11 March | Newcastle Knights | 40 – 44 | Gold Coast Titans | McDonald Jones Stadium | View |
| 11 March | Manly Sea Eagles | 52 – 20 | South Sydney Rabbitohs | Lottoland | View |
| 11 March | Canberra Raiders | 12 – 74 | Cronulla Sharks | GIO Stadium | View |
| 12 March | Wests Tigers | 4 – 36 | Penrith Panthers | Campbelltown Stadium | View |
| 12 March | St George Illawarra Dragons | 26 – 22 | Parramatta Eels | WIN Stadium | View |
| Round 3 | |||||
| 17 March | Gold Coast Titans | 28 – 36 | Parramatta Eels | Cbus Super Stadium | View |
| 18 March | Newcastle Knights | 26 – 22 | South Sydney Rabbitohs | McDonald Jones Stadium | View |
| 18 March | Canterbury Bulldogs | 24 – 22 | Warriors | Belmore Sports Ground | View |
| 18 March | Melbourne Storm | 28 – 24 | Brisbane Broncos | Maroochydore JRL | View |
| 18 March | Penrith Panthers | 38 – 12 | Sydney Roosters | Pepper Stadium | View |
| 18 March | North Queensland Cowboys | 28 – 20 | Manly Sea Eagles | 1300SMILES Stadium | View |
| 19 March | Canberra Raiders | 54 – 10 | Wests Tigers | GIO Stadium | View |
| 19 March | Cronulla Sharks | 38 – 4 | St George Illawarra Dragons | S. Cross Group Stadium | View |
| Round 4 | |||||
| 23 March | South Sydney Rabbitohs | 40 – 8 | Sydney Roosters | ANZ Stadium | View |
| 24 March | Penrith Panthers | 40 – 16 | Newcastle Knights | Pepper Stadium | View |
| 24 March | Brisbane Broncos | 24 – 16 | Canberra Raiders | Suncorp Stadium | View |
| 25 March | Manly Sea Eagles | 22 – 30 | Canterbury Bulldogs | Lottoland | View |
| 25 March | Parramatta Eels | 22 – 12 | Cronulla Sharks | ANZ Stadium | View |
| 26 March | Wests Tigers | 24 – 62 | Melbourne Storm | Leichhardt Oval | View |
| 26 Marh | St George Illawarra Dragons | 48 – 24 | Warriors | UOW Jubilee Oval | View |
| 6 May | Gold Coast Titans | 30 – 26 | North Queensland Cowboys | Ned Byrne Oval | View |
| Round 5 | |||||
| 31 March | Sydney Roosters | 66 – 14 | Manly Sea Eagles | Allianz Stadium | View |
| 31 March | North Queensland Cowboys | 42 – 18 | South Sydney Rabbitohs | 1300SMILES Stadium | View |
| 1 April | Cronulla Sharks | 32 – 22 | Newcastle Knights | S. Cross Group Stadium | View |
| 1 April | Canterbury Bulldogs | 12 – 26 | Brisbane Broncos | Belmore Sports Ground | View |
| 1 April | Canberra Raiders | 42 – 22 | Parramatta Eels | GIO Stadium | View |
| 1 April | Melbourne Storm | 20 – 36 | Penrith Panthers | Sunshine Coast Stadium | View |
| 2 April | Warriors | 30 – 34 | Gold Coast Titans | Mt Smart Stadium | View |
| 2 April | Wests Tigers | 22 – 30 | St George Illawarra Dragons | ANZ Stadium | View |
| Round 6 | |||||
| 6 April | Brisbane Broncos | 40 – 26 | Sydney Roosters | Suncorp Stadium | View |
| 7 April | Newcastle Knights | 22 – 12 | Canterbury Bulldogs | McDonald Jones Stadium | View |
| 7 April | Penrith Panthers | 28 – 24 | South Sydney Rabbitohs | Pepper Stadium | View |
| 8 April | Melbourne Storm | 22 – 36 | Cronulla Sharks | Sunshine Coast Stadium | View |
| 8 April | Gold Coast Titans | 32 – 24 | Canberra Raiders | Cbus Super Stadium | View |
| 8 April | North Queensland Cowboys | 20 – 26 | Wests Tigers | 1300SMILES Stadium | View |
| 9 April | Manly Sea Eagles | 26 – 32 | St George Illawarra Dragons | New Era Stadium | View |
| 9 April | Warriors | 23 – 34 | Parramatta Eels | Mt Smart Stadium | View |
| Round 7 | |||||
| 14 April | Canterbury Bulldogs | 30 – 24 | South Sydney Rabbitohs | ANZ Stadium | View |
| 14 April | Newcastle Knights | 22 – 20 | Sydney Roosters | McDonald Jones Stadium | View |
| 14 April | Brisbane Broncos | 20 – 24 | Gold Coast Titans | Suncorp Stadium | View |
| 15 April | Manly Sea Eagles | 24 – 14 | Melbourne Storm | Pittwater Rugby Park | View |
| 15 April | Canberra Raiders | 18 – 16 | Warriors | GIO Stadium | View |
| 15 April | St George Illawarra Dragons | 6 – 40 | North Queensland Cowboys | WIN Stadium | View |
| 16 April | Penrith Panthers | 30 – 30 | Cronulla Sharks | Pepper Stadium | View |
| 17 April | Parramatta Eels | 48 – 16 | Wests Tigers | ANZ Stadium | View |
| Round 8 | |||||
| 21 April | Canberra Raiders | 36 – 14 | Manly Sea Eagles | GIO Stadium | View |
| 21 April | South Sydney Rabbitohs | 16 – 34 | Brisbane Broncos | ANZ Stadium | View |
| 22 April | Parramatta Eels | 32 – 36 | Penrith Panthers | ANZ Stadium | View |
| 22 April | North Queensland Cowboys | 54 – 12 | Newcastle Knights | 1300SMILES Stadium | View |
| 22 April | Cronulla Sharks | 52 – 16 | Gold Coast Titans | S. Cross Group Stadium | View |
| 23 April | Wests Tigers | 20 – 20 | Canterbury Bulldogs | ANZ Stadium | View |
| 23 April | Melbourne Storm | 36 – 20 | Warriors | Sunshine Coast Stadium | View |
| 25 April | Sydney Roosters | 26 – 35 | St George Illawarra Dragons | Allianz Stadium | View |
| Round 9 | |||||
| 27 April | Brisbane Broncos | 12 – 44 | Penrith Panthers | Suncorp Stadium | View |
| 28 April | South Sydney Rabbitohs | 20 – 30 | Manly Sea Eagles | Allianz Stadium | View |
| 28 April | North Queensland Cowboys | 12 – 60 | Parramatta Eels | 1300SMILES Stadium | View |
| 29 April | Gold Coast Titans | 22 – 50 | Newcastle Knights | Cbus Super Stadium | View |
| 29 April | Canterbury Bulldogs | 22 – 26 | Canberra Raiders | Belmore Sports Ground | View |
| 29 April | Wests Tigers | 18 – 34 | Cronulla Sharks | Leichhardt Oval | View |
| 30 April | Warriors | 16 – 24 | Sydney Roosters | Mt Smart Stadium | View |
| 30 April | St George Illawarra Dragons | 46 – 24 | Melbourne Storm | WIN Stadium | View |
| Round 10 | |||||
| 12 May | St George Illawarra Dragons | 14 – 36 | Cronulla Sharks | UOW Jubilee Oval | View |
| 12 May | Wests Tigers | 0 – 18 | South Sydney Rabbitohs | ANZ Stadium | View |
| 13 May | Penrith Panthers | 38 – 16 | Warriors | Pepper Stadium | View |
| 13 May | Canterbury Bulldogs | 22 – 16 | North Queensland Cowboys | Belmore Sports Ground | View |
| 13 May | Manly Sea Eagles | 46 – 10 | Brisbane Broncos | Lottoland | View |
| 13 May | Melbourne Storm | 32 – 44 | Gold Coast Titans | Suzuki Stadium | View |
| 14 May | Newcastle Knights | 32 – 6 | Canberra Raiders | McDonald Jones Stadium | View |
| 14 May | Sydney Roosters | 28 – 30 | Parramatta Eels | Allianz Stadium | View |
| Round 11 | |||||
| 18 May | Cronulla Sharks | 40 – 24 | North Queensland Cowboys | S. Cross Group Stadium | View |
| 19 May | Warriors | 22 – 24 | St George Illawarra Dragons | FMG Stadium Waikato | View |
| 19 May | Brisbane Broncos | 12 – 22 | Wests Tigers | Suncorp Stadium | View |
| 20 May | South Sydney Rabbitohs | 44 – 18 | Melbourne Storm | Redfern Oval | View |
| 20 May | Gold Coast Titans | 36 – 12 | Manly Sea Eagles | Cbus Super Stadium | View |
| 20 May | Parramatta Eels | 23 – 22 | Canberra Raiders | ANZ Stadium | View |
| 21 May | Newcastle Knights | 28 – 22 | Penrith Panthers | McDonald Jones Stadium | View |
| 21 May | Canterbury Bulldogs | 14 – 44 | Sydney Roosters | ANZ Stadium | View |
| Round 12 | |||||
| 26 May | South Sydney Rabbitohs | 28 – 26 | Parramatta Eels | ANZ Stadium | View |
| 27 May | Warriors | 36 – 20 | Brisbane Broncos | Mt Smart Stadium | View |
| 27 May | Cronulla Sharks | 30 – 10 | Canterbury Bulldogs | S. Cross Group Stadium | View |
| 28 May | Canberra Raiders | 32 – 24 | Sydney Roosters | GIO Stadium | View |
| Gold Coast Titans | BYE | ||||
| Manly Sea Eagles | BYE | ||||
| Melbourne Storm | BYE | ||||
| Newcastle Knights | BYE | ||||
| North Queensland Cowboys | BYE | ||||
| Penrith Panthers | BYE | ||||
| St George Illawarra Dragons | BYE | ||||
| Wests Tigers | BYE |
| Round 13 | |||||
| 2 June | Parramatta Eels | 22 – 6 | Warriors | ANZ Stadium | View |
| 3 June | Melbourne Storm | 20 – 27 | Newcastle Knights | Sunshine Coast Stadium | View |
| 3 June | St George Illawarra Dragons | 54 – 16 | Wests Tigers | ANZ Stadium | View |
| 3 June | Canterbury Bulldogs | 12 – 28 | Penrith Panthers | Belmore Sports Ground | View |
| 3 June | Sydney Roosters | 14 – 22 | Brisbane Broncos | Allianz Stadium | View |
| 3 June | North Queensland Cowboys | 36 – 18 | Gold Coast Titans | 1300SMILES Stadium | View |
| 4 June | Manly Sea Eagles | 34 – 18 | Canberra Raiders | Lottoland | View |
| Cronulla Sharks | BYE | ||||
| South Sydney Rabbitohs | BYE |
| Round 14 | |||||
| 8 June | Cronulla Sharks | 28 – 20 | Melbourne Storm | S. Cross Group Stadium | View |
| 9 June | Manly Sea Eagles | 32 – 12 | Newcastle Knights | Lottoland | View |
| 9 June | Brisbane Broncos | 22 – 28 | South Sydney Rabbitohs | Suncorp Stadium | View |
| 10 June | Parramatta Eels | 4 – 40 | North Queensland Cowboys | Ringrose Park | View |
| 10 June | Gold Coast Titans | 18 – 20 | Warriors | Cbus Super Stadium | View |
| 10 June | Penrith Panthers | 28 – 22 | Canberra Raiders | Pepper Stadium | View |
| 11 June | Wests Tigers | 28 – 42 | Sydney Roosters | Campbelltown Stadium | View |
| 12 June | Canterbury Bulldogs | 26 – 28 | St George Illawarra Dragons | ANZ Stadium | View |
| Round 15 | |||||
| 16 June | South Sydney Rabbitohs | 26 – 18 | Gold Coast Titans | ANZ Stadium | View |
| 17 June | Melbourne Storm | 22 – 20 | North Queensland Cowboys | AAMI Park | View |
| 17 June | Cronulla Sharks | 84 – 6 | Wests Tigers | S. Cross Group Stadium | View |
| 18 June | Parramatta Eels | 30 – 32 | St George Illawarra Dragons | ANZ Stadium | View |
| Brisbane Broncos | BYE | ||||
| Canberra Raiders | BYE | ||||
| Canterbury Bulldogs | BYE | ||||
| Manly Sea Eagles | BYE | ||||
| Newcastle Knights | BYE | ||||
| Penrith Panthers | BYE | ||||
| Sydney Roosters | BYE | ||||
| Warriors | BYE |
| Round 16 | |||||
| 23 June | Warriors | 36 – 6 | Canterbury Bulldogs | Mt Smart Stadium | View |
| 23 June | Wests Tigers | 14 – 28 | Gold Coast Titans | Campbelltown Stadium | View |
| 24 June | North Queensland Cowboys | 24 – 18 | Penrith Panthers | 1300SMILES Stadium | View |
| 24 June | Sydney Roosters | 34 – 35 | Melbourne Storm | Morry Breen Oval | View |
| 24 June | Canberra Raiders | 20 – 34 | Brisbane Broncos | GIO Stadium | View |
| 25 June | St George Illawarra Dragons | 21 – 16 | Newcastle Knights | UOW Jubilee Oval | View |
| 25 June | Cronulla Sharks | 34 – 30 | Manly Sea Eagles | S. Cross Group Stadium | View |
| Parramatta Eels | BYE | ||||
| South Sydney Rabbitohs | BYE |
| Round 17 | |||||
| 29 June | Parramatta Eels | 18 – 26 | Canterbury Bulldogs | ANZ Stadium | View |
| 30 June | Gold Coast Titans | 26 – 24 | St George Illawarra Dragons | Cbus Super Stadium | View |
| 30 June | Brisbane Broncos | 48 – 18 | Melbourne Storm | Suncorp Stadium | View |
| 1 July | Sydney Roosters | 18 – 32 | Cronulla Sharks | Central Coast Stadium | View |
| 1 July | Manly Sea Eagles | 58 – 12 | Warriors | Lottoland | View |
| 1 July | Canberra Raiders | 36 – 14 | North Queensland Cowboys | GIO Stadium | View |
| 2 July | Newcastle Knights | 28 – 18 | Wests Tigers | McDonald Jones Stadium | View |
| 2 July | South Sydney Rabbitohs | 16 – 16 | Penrith Panthers | ANZ Stadium | View |
| Round 18 | |||||
| 7 July | Sydney Roosters | 24 – 24 | South Sydney Rabbitohs | Allianz Stadium | View |
| 8 July | Penrith Panthers | 20 – 28 | Manly Sea Eagles | Pepper Stadium | View |
| 8 July | Melbourne Storm | 16 – 48 | Parramatta Eels | Sunshine Coast Stadium | View |
| 9 July | Canterbury Bulldogs | 28 – 28 | Newcastle Knights | Belmore Sports Ground | View |
| Brisbane Broncos | BYE | ||||
| Canberra Raiders | BYE | ||||
| Cronulla Sharks | BYE | ||||
| Gold Coast Titans | BYE | ||||
| North Queensland Cowboys | BYE | ||||
| St George Illawarra Dragons | BYE | ||||
| Warriors | BYE | ||||
| Wests Tigers | BYE |
| Round 19 | |||||
| 14 July | Warriors | 4 – 28 | Penrith Panthers | Mt Smart Stadium | View |
| 14 July | Canberra Raiders | 18 – 12 | St George Illawarra Dragons | GIO Stadium | View |
| 15 July | South Sydney Rabbitohs | 32 – 18 | North Queensland Cowboys | Redfern Oval | View |
| 15 July | Newcastle Knights | 12 – 40 | Brisbane Broncos | McDonald Jones Stadium | View |
| 15 July | Gold Coast Titans | 12 – 32 | Cronulla Sharks | Cbus Super Stadium | View |
| 16 June | Manly Sea Eagles | 32 – 22 | Wests Tigers | Lottoland | View |
| Canterbury Bulldogs | BYE | ||||
| Melbourne Storm | BYE | ||||
| Parramatta Eels | BYE | ||||
| Sydney Roosters | BYE |
| Round 20 | |||||
| 21 July | Sydney Roosters | 42 – 22 | Newcastle Knights | Allianz Stadium | View |
| 21 July | Cronulla Sharks | 40 – 14 | South Sydney Rabbitohs | S. Cross Group Stadium | View |
| 22 July | Penrith Panthers | 32 – 52 | Gold Coast Titans | Pepper Stadium | View |
| 22 July | Brisbane Broncos | 48 – 14 | Canterbury Bulldogs | Kev McKell Oval | View |
| 22 July | Canberra Raiders | 24 – 36 | Melbourne Storm | GIO Stadium | View |
| 22 July | North Queensland Cowboys | 70 – 10 | Warriors | 1300SMILES Stadium | View |
| 23 July | St George Illawarra Dragons | 46 – 22 | Manly Sea Eagles | WIN Stadium | View |
| 23 July | Wests Tigers | 20 – 24 | Parramatta Eels | ANZ Stadium | View |
| Round 21 | |||||
| 27 July | Penrith Panthers | 36 – 18 | Canterbury Bulldogs | Pepper Stadium | View |
| 28 July | Warriors | 4 – 42 | Cronulla Sharks | Mt Smart Stadium | View |
| 28 July | Parramatta Eels | 20 – 12 | Brisbane Broncos | ANZ Stadium | View |
| 29 July | Newcastle Knights | 30 – 22 | St George Illawarra Dragons | McDonald Jones Stadium | View |
| 29 July | Melbourne Storm | 26 – 34 | Manly Sea Eagles | Sunshine Coast Stadium | View |
| 29 July | South Sydney Rabbitohs | 46 – 16 | Canberra Raiders | ANZ Stadium | View |
| 29 July | Sydney Roosters | 30 – 34 | North Queensland Cowboys | Allianz Stadium | View |
| 30 July | Gold Coast Titans | 26 – 26 | Wests Tigers | Cbus Super Stadium | View |
| Round 22 | |||||
| 3 August | Canterbury Bulldogs | 14 – 36 | Parramatta Eels | ANZ Stadium | View |
| 4 August | St George Illawarra Dragons | 16 – 38 | South Sydney Rabbitohs | Allianz Stadium | View |
| 4 August | North Queensland Cowboys | 50 – 6 | Melbourne Storm | 1300SMILES Stadium | View |
| 5 August | Newcastle Knights | 70 – 4 | Warriors | McDonald Jones Stadium | View |
| 5 August | Gold Coast Titans | 34 – 36 | Brisbane Broncos | Cbus Super Stadium | View |
| 5 August | Cronulla Sharks | 58 – 22 | Canberra Raiders | S. Cross Group Stadium | View |
| 6 August | Manly Sea Eagles | 32 – 38 | Sydney Roosters | Lottoland | View |
| 6 August | Penrith Panthers | 38 – 12 | Wests Tigers | Pepper Stadium | View |
| Round 23 | |||||
| 10 August | South Sydney Rabbitohs | 28 – 24 | Canterbury Bulldogs | ANZ Stadium | View |
| 11 August | Parramatta Eels | 50 – 12 | Newcastle Knights | ANZ Stadium | View |
| 11 August | Brisbane Broncos | 12 – 40 | Cronulla Sharks | Suncorp Stadium | View |
| 12 August | St George Illawarra Dragons | 36 – 12 | Gold Coast Titans | UOW Jubilee Oval | View |
| 12 August | Melbourne Storm | 16 – 42 | Sydney Roosters | Sunshine Coast Stadium | View |
| 12 August | Penrith Panthers | 16 – 40 | North Queensland Cowboys | Pepper Stadium | View |
| 13 August | Warriors | 14 – 36 | Canberra Raiders | Mt Smart Stadium | View |
| 13 August | Wests Tigers | 36 – 30 | Manly Sea Eagles | Leichhardt Oval | View |
| Round 24 | |||||
| 18 August | Parramatta Eels | 38 – 16 | Gold Coast Titans | Belmore Sports Ground | View |
| 18 August | Brisbane Broncos | 46 – 12 | St George Illawarra Dragons | Suncorp Stadium | View |
| 18 August | Canterbury Bulldogs | 6 – 36 | Manly Sea Eagles | Belmore Sports Ground | View |
| 19 August | Newcastle Knights | 18 – 54 | Melbourne Storm | McDonald Jones Stadium | View |
| 19 August | South Sydney Rabbitohs | 68 – 10 | Warriors | Redfern Oval | View |
| 19 August | Sydney Roosters | 60 – 18 | Wests Tigers | Allianz Stadium | View |
| 19 August | North Queensland Cowboys | 12 – 36 | Cronulla Sharks | 1300SMILES Stadium | View |
| 20 August | Canberra Raiders | 28 – 48 | Penrith Panthers | GIO Stadium | View |
| Round 25 | |||||
| 24 August | Brisbane Broncos | 14 – 8 | Parramatta Eels | Suncorp Stadium | View |
| 25 August | Canberra Raiders | 20 – 21 | Newcastle Knights | GIO Stadium | View |
| 25 August | Wests Tigers | 18 – 26 | North Queensland Cowboys | Campbelltown Stadium | View |
| 26 August | Gold Coast Titans | 20 – 28 | Canterbury Bulldogs | Cbus Super Stadium | View |
| 26 August | Melbourne Storm | 10 – 44 | South Sydney Rabbitohs | Sunshine Coast Stadium | View |
| 26 August | Cronulla Sharks | 18 – 26 | Sydney Roosters | S. Cross Group Stadium | View |
| 27 August | Warriors | 12 – 52 | Manly Sea Eagles | Mt Smart Stadium | View |
| 27 August | Penrith Panthers | 10 – 40 | St George Illawarra Dragons | Pepper Stadium | View |
| Round 26 | |||||
| 31 August | North Queensland Cowboys | 24 – 26 | Brisbane Broncos | 1300SMILES Stadium | View |
| 1 September | Parramatta Eels | 40 – 26 | South Sydney Rabbitohs | ANZ Stadium | View |
| 2 September | Sydney Roosters | 60 – 24 | Gold Coast Titans | Allianz Stadium | View |
| 2 September | Manly Sea Eagles | 29 – 10 | Penrith Panthers | Lottoland | View |
| 3 September | Melbourne Storm | 22 – 24 | Canberra Raiders | Kawana Sports Precinct | View |
| 3 September | Newcastle Knights | 36 – 24 | Cronulla Sharks | McDonald Jones Stadium | View |
| 3 September | St George Illawarra Dragons | 34 – 34 | Canterbury Bulldogs | ANZ Stadium | View |
| 3 September | Wests Tigers | 54 – 16 | Warriors | Leichhardt Oval | View |