| Round 1 | |||||
| 3 March | Parramatta Eels | 32 – 18 | Brisbane Broncos | Pirtek Stadium | View |
| 4 March | Manly Sea Eagles | 12 – 40 | Canterbury Bulldogs | Brookvale Oval | View |
| 5 March | Canberra Raiders | 36 – 34 | Penrith Panthers | GIO Stadium | View |
| 5 March | Wests Tigers | 26 – 12 | Warriors | Campbelltown Stadium | View |
| 5 March | North Queensland Cowboys | 16 – 30 | Cronulla Sharks | 1300SMILES Stadium | View |
| 6 March | Sydney Roosters | 40 – 20 | South Sydney Rabbitohs | Allianz Stadium | View |
| 6 March | Melbourne Storm | 44 – 24 | St George Illawarra Dragons | Sunshine Coast Stadium | View |
| 6 March | Gold Coast Titans | 18 – 34 | Newcastle Knights | Cbus Super Stadium | View |
| Round 2 | |||||
| 10 March | Penrith Panthers | 46 – 6 | Canterbury Bulldogs | Pepper Stadium | View |
| 11 March | Brisbane Broncos | 14 – 8 | Warriors | Suncorp Stadium | View |
| 12 March | Canberra Raiders | 22 – 32 | Sydney Roosters | GIO Stadium | View |
| 12 March | South Sydney Rabbitohs | 28 – 14 | Newcastle Knights | ANZ Stadium | View |
| 12 March | Melbourne Storm | 42 – 44 | Gold Coast Titans | Suzuki Stadium | View |
| 12 March | Parramatta Eels | 12 – 34 | North Queensland Cowboys | Pirtek Stadium | View |
| 13 March | Cronulla Sharks | 26 – 24 | St George Illawarra Dragons | S. Cross Group Stadium | View |
| 14 March | Wests Tigers | 34 – 30 | Manly Sea Eagles | Leichhardt Oval | View |
| Round 3 | |||||
| 17 March | North Queensland Cowboys | 36 – 16 | Sydney Roosters | 1300SMILES Stadium | View |
| 18 March | Canterbury Bulldogs | 20 – 30 | Parramatta Eels | ANZ Stadium | View |
| 19 March | Newcastle Knights | 28 – 46 | Canberra Raiders | Hunter Stadium | View |
| 19 March | Penrith Panthers | 48 – 16 | Brisbane Broncos | Pepper Stadium | View |
| 19 March | Gold Coast Titans | 30 – 18 | Wests Tigers | Cbus Super Stadium | View |
| 20 March | Warriors | 30 – 16 | Melbourne Storm | Mt Smart Stadium | View |
| 20 March | St George Illawarra Dragons | 26 – 24 | South Sydney Rabbitohs | Sydney Cricket Ground | View |
| 7 May | Manly Sea Eagles | 22 – 16 | Cronulla Sharks | Brookvale Oval | View |
| Round 4 | |||||
| 25 March | South Sydney Rabbitohs | 28 – 10 | Canterbury Bulldogs | ANZ Stadium | View |
| 25 March | Brisbane Broncos | 22 – 23 | North Queensland Cowboys | Suncorp Stadium | View |
| 26 March | Canberra Raiders | 20 – 42 | Gold Coast Titans | GIO Stadium | View |
| 26 March | Sydney Roosters | 42 – 23 | Manly Sea Eagles | Allianz Stadium | View |
| 27 March | St George Illawarra Dragons | 12 – 28 | Penrith Panthers | WIN Stadium | View |
| 28 March | Warriors | 12 – 26 | Newcastle Knights | Mt Smart Stadium | View |
| 28 March | Wests Tigers | 4 – 40 | Parramatta Eels | ANZ Stadium | View |
| 28 March | Cronulla Sharks | 48 – 40 | Melbourne Storm | S. Cross Group Stadium | View |
| Round 5 | |||||
| 31 March | Manly Sea Eagles | 24 – 32 | South Sydney Rabbitohs | Brookvale Oval | View |
| 1 April | Gold Coast Titans | 10 – 48 | Brisbane Broncos | Cbus Super Stadium | View |
| 2 April | Melbourne Storm | 26 – 34 | Newcastle Knights | AAMI Park | View |
| 2 April | Wests Tigers | 42 – 24 | Cronulla Sharks | Campbelltown Stadium | View |
| 2 April | North Queensland Cowboys | 38 – 18 | St George Illawarra Dragons | 1300SMILES Stadium | View |
| 3 April | Sydney Roosters | 44 – 6 | Warriors | Central Coast Stadium | View |
| 3 April | Parramatta Eels | 4 – 42 | Penrith Panthers | Pirtek Stadium | View |
| 4 April | Canterbury Bulldogs | 18 – 24 | Canberra Raiders | Belmore Sports Ground | View |
| Round 6 | |||||
| 7 April | Brisbane Broncos | 12 – 38 | St George Illawarra Dragons | Suncorp Stadium | View |
| 8 April | South Sydney Rabbitohs | 16 – 36 | Sydney Roosters | ANZ Stadium | View |
| 9 April | Parramatta Eels | 34 – 20 | Canberra Raiders | Pirtek Stadium | View |
| 9 April | Melbourne Storm | 60 – 10 | Canterbury Bulldogs | Sunshine Coast Stadium | View |
| 9 April | Warriors | 28 – 20 | Manly Sea Eagles | Mt Smart Stadium | View |
| 9 April | Penrith Panthers | 36 – 10 | North Queensland Cowboys | Pepper Stadium | View |
| 10 April | Cronulla Sharks | 32 – 20 | Gold Coast Titans | S. Cross Group Stadium | View |
| 10 April | Newcastle Knights | 30 – 30 | Wests Tigers | Hunter Stadium | View |
| Round 7 | |||||
| 14 April | Manly Sea Eagles | 6 – 36 | Parramatta Eels | Brookvale Oval | View |
| 15 April | North Queensland Cowboys | 18 – 34 | South Sydney Rabbitohs | 1300SMILES Stadium | View |
| 16 April | Canterbury Bulldogs | 30 – 26 | Warriors | Belmore Sports Ground | View |
| 16 April | Gold Coast Titans | 39 – 32 | St George Illawarra Dragons | Cbus Super Stadium | View |
| 16 April | Brisbane Broncos | 18 – 19 | Newcastle Knights | Suncorp Stadium | View |
| 17 April | Canberra Raiders | 6 – 32 | Cronulla Sharks | GIO Stadium | View |
| 17 April | Wests Tigers | 44 – 12 | Melbourne Storm | Leichhardt Oval | View |
| 18 April | Sydney Roosters | 4 – 50 | Penrith Panthers | Allianz Stadium | View |
| Round 8 | |||||
| 22 April | Brisbane Broncos | 38 – 0 | South Sydney Rabbitohs | Suncorp Stadium | View |
| 23 April | Canterbury Bulldogs | 36 – 12 | Gold Coast Titans | ANZ Stadium | View |
| 23 April | Canberra Raiders | 16 – 50 | Wests Tigers | GIO Stadium | View |
| 23 April | North Queensland Cowboys | 54 – 12 | Parramatta Eels | 1300SMILES Stadium | View |
| 24 April | Melbourne Storm | 28 – 36 | Warriors | Sunshine Coast Stadium | View |
| 24 April | Cronulla Sharks | 14 – 24 | Penrith Panthers | S. Cross Group Stadium | View |
| 25 April | Newcastle Knights | 30 – 24 | Manly Sea Eagles | Hunter Stadium | View |
| 25 April | St George Illawarra Dragons | 38 – 26 | Sydney Roosters | Allianz Stadium | View |
| Round 9 | |||||
| 28 April | South Sydney Rabbitohs | 0 – 46 | Wests Tigers | ANZ Stadium | View |
| 29 April | Parramatta Eels | 36 – 12 | Canterbury Bulldogs | ANZ Stadium | View |
| 30 April | Penrith Panthers | 74 – 10 | Canberra Raiders | Carrington Park | View |
| 30 April | Sydney Roosters | 34 – 16 | Newcastle Knights | Allianz Stadium | View |
| 30 April | Manly Sea Eagles | 22 – 34 | North Queensland Cowboys | Brookvale Oval | View |
| 1 May | Warriors | 0 – 50 | St George Illawarra Dragons | Mt Smart Stadium | View |
| 1 May | Gold Coast Titans | 18 – 26 | Melbourne Storm | Cbus Super Stadium | View |
| 1 May | Cronulla Sharks | 36 – 26 | Brisbane Broncos | S. Cross Group Stadium | View |
| Round 10 | |||||
| 12 May | St George Illawarra Dragons | 44 – 6 | Canberra Raiders | UOW Jubilee Oval | View |
| 13 May | Parramatta Eels | 28 – 22 | South Sydney Rabbitohs | Pirtek Stadium | View |
| 14 May | Penrith Panthers | 74 – 10 | Warriors | Pepper Stadium | View |
| 14 May | Manly Sea Eagles | 22 – 32 | Brisbane Broncos | Brookvale Oval | View |
| 14 May | Melbourne Storm | 38 – 44 | North Queensland Cowboys | Suzuki Stadium | View |
| 15 May | Newcastle Knights | 10 – 30 | Cronulla Sharks | Hunter Stadium | View |
| 15 May | Wests Tigers | 42 – 10 | Canterbury Bulldogs | ANZ Stadium | View |
| 16 May | Gold Coast Titans | 16 – 34 | Sydney Roosters | Cbus Super Stadium | View |
| Round 11 | |||||
| 19 May | South Sydney Rabbitohs | 22 – 34 | St George Illawarra Dragons | ANZ Stadium | View |
| 20 May | North Queensland Cowboys | 38 – 18 | Brisbane Broncos | 1300SMILES Stadium | View |
| 21 May | Wests Tigers | 32 – 28 | Newcastle Knights | Campbelltown Stadium | View |
| 21 May | Cronulla Sharks | 30 – 16 | Manly Sea Eagles | S. Cross Group Stadium | View |
| 22 May | Warriors | 20 – 4 | Canberra Raiders | Mt Smart No. 2 Stadium | View |
| 22 May | Penrith Panthers | 28 – 24 | Gold Coast Titans | Pepper Stadium | View |
| 22 May | Parramatta Eels | 38 – 14 | Melbourne Storm | McCredie Park | View |
| 22 May | Canterbury Bulldogs | 46 – 16 | Sydney Roosters | ANZ Stadium | View |
| Round 12 | |||||
| 27 May | Brisbane Broncos | 38 – 12 | Wests Tigers | Suncorp Stadium | View |
| 28 May | St George Illawarra Dragons | 30 – 30 | North Queensland Cowboys | WIN Stadium | View |
| 29 May | Canberra Raiders | 36 – 34 | Canterbury Bulldogs | GIO Stadium | View |
| 30 May | Newcastle Knights | 36 – 24 | Parramatta Eels | Hunter Stadium | View |
| Cronulla Sharks | BYE | ||||
| Gold Coast Titans | BYE | ||||
| Manly Sea Eagles | BYE | ||||
| Melbourne Storm | BYE | ||||
| Penrith Panthers | BYE | ||||
| South Sydney Rabbitohs | BYE | ||||
| Sydney Roosters | BYE | ||||
| Warriors | BYE |
| Round 13 | |||||
| 3 June | Canberra Raiders | 38 – 14 | Manly Sea Eagles | GIO Stadium | View |
| 4 June | Warriors | 34 – 22 | Brisbane Broncos | Mt Smart Stadium | View |
| 4 June | South Sydney Rabbitohs | 12 – 14 | Gold Coast Titans | North Sydney Oval | View |
| 4 June | North Queensland Cowboys | 66 – 16 | Newcastle Knights | 1300SMILES Stadium | View |
| 18 June | Canterbury Bulldogs | 18 – 20 | Cronulla Sharks | ANZ Stadium | View |
| 13 July | Sydney Roosters | 20 – 14 | Wests Tigers | Allianz Stadium | View |
| Cancelled | Melbourne Storm | 0 – 0 | Penrith Panthers | Sunshine Coast Stadium | View |
| Parramatta Eels | BYE | ||||
| St George Illawarra Dragons | BYE |
| Round 14 | |||||
| 10 June | Wests Tigers | 40 – 14 | South Sydney Rabbitohs | ANZ Stadium | View |
| 11 June | Newcastle Knights | 24 – 18 | Warriors | Hunter Stadium | View |
| 11 June | Brisbane Broncos | 36 – 10 | Canberra Raiders | Bishop Park | View |
| 11 June | Sydney Roosters | 42 – 20 | Melbourne Storm | Allianz Stadium | View |
| 12 June | Manly Sea Eagles | 6 – 60 | Penrith Panthers | Brookvale Oval | View |
| 12 June | Parramatta Eels | 30 – 10 | Gold Coast Titans | Ringrose Park | View |
| 13 June | St George Illawarra Dragons | 30 – 28 | Canterbury Bulldogs | ANZ Stadium | View |
| 13 June | Cronulla Sharks | 28 – 35 | North Queensland Cowboys | S. Cross Group Stadium | View |
| Round 15 | |||||
| 17 June | South Sydney Rabbitohs | 16 – 22 | Parramatta Eels | ANZ Stadium | View |
| 18 June | St George Illawarra Dragons | 38 – 30 | Melbourne Storm | WIN Stadium | View |
| 19 June | Warriors | 40 – 20 | Sydney Roosters | Mt Smart Stadium | View |
| 20 June | Gold Coast Titans | 54 – 24 | Manly Sea Eagles | Cbus Super Stadium | View |
| Brisbane Broncos | BYE | ||||
| Canberra Raiders | BYE | ||||
| Canterbury Bulldogs | BYE | ||||
| Cronulla Sharks | BYE | ||||
| Newcastle Knights | BYE | ||||
| North Queensland Cowboys | BYE | ||||
| Penrith Panthers | BYE | ||||
| Wests Tigers | BYE |
| Round 16 | |||||
| 24 June | Penrith Panthers | 32 – 8 | South Sydney Rabbitohs | Pepper Stadium | View |
| 25 June | Newcastle Knights | 6 – 36 | St George Illawarra Dragons | Hunter Stadium | View |
| 25 June | Melbourne Storm | 38 – 12 | Wests Tigers | Sunshine Coast Stadium | View |
| 25 June | Cronulla Sharks | 32 – 36 | Warriors | S. Cross Group Stadium | View |
| 25 June | Canterbury Bulldogs | 38 – 22 | Brisbane Broncos | ANZ Stadium | View |
| 26 June | Gold Coast Titans | 32 – 34 | Canberra Raiders | Cbus Super Stadium | View |
| 27 June | North Queensland Cowboys | 40 – 10 | Manly Sea Eagles | 1300SMILES Stadium | View |
| Parramatta Eels | BYE | ||||
| Sydney Roosters | BYE |
| Round 17 | |||||
| 30 June | Sydney Roosters | 34 – 20 | Canterbury Bulldogs | Allianz Stadium | View |
| 1 July | Brisbane Broncos | 18 – 30 | Melbourne Storm | Suncorp Stadium | View |
| 2 July | Warriors | 14 – 12 | Gold Coast Titans | Mt Smart Stadium | View |
| 2 July | South Sydney Rabbitohs | 26 – 18 | North Queensland Cowboys | Redfern Oval | View |
| 2 July | Wests Tigers | 16 – 24 | Penrith Panthers | ANZ Stadium | View |
| 2 July | Cronulla Sharks | 36 – 10 | Parramatta Eels | S. Cross Group Stadium | View |
| 3 July | Canberra Raiders | 34 – 24 | Newcastle Knights | GIO Stadium | View |
| 4 July | Manly Sea Eagles | 10 – 38 | St George Illawarra Dragons | Brookvale Oval | View |
| Round 18 | |||||
| 8 July | Parramatta Eels | 30 – 12 | Sydney Roosters | Pirtek Stadium | View |
| 8 July | Canterbury Bulldogs | 20 – 20 | Wests Tigers | Belmore Sports Ground | View |
| 9 July | Canberra Raiders | 18 – 12 | North Queensland Cowboys | Workers Arena | View |
| 10 July | Penrith Panthers | 34 – 34 | Cronulla Sharks | Pepper Stadium | View |
| Brisbane Broncos | BYE | ||||
| Gold Coast Titans | BYE | ||||
| Manly Sea Eagles | BYE | ||||
| Melbourne Storm | BYE | ||||
| Newcastle Knights | BYE | ||||
| South Sydney Rabbitohs | BYE | ||||
| St George Illawarra Dragons | BYE | ||||
| Warriors | BYE |
| Round 19 | |||||
| 15 July | St George Illawarra Dragons | 30 – 22 | Gold Coast Titans | UOW Jubilee Oval | View |
| 16 July | South Sydney Rabbitohs | 20 – 52 | Brisbane Broncos | ANZ Stadium | View |
| 17 July | Newcastle Knights | 24 – 26 | Melbourne Storm | Hunter Stadium | View |
| 17 July | Manly Sea Eagles | 32 – 22 | Warriors | Brookvale Oval | View |
| 17 July | Penrith Panthers | 24 – 16 | Parramatta Eels | Pepper Stadium | View |
| 18 July | Sydney Roosters | 38 – 28 | Cronulla Sharks | Allianz Stadium | View |
| Canberra Raiders | BYE | ||||
| Canterbury Bulldogs | BYE | ||||
| North Queensland Cowboys | BYE | ||||
| Wests Tigers | BYE |
| Round 20 | |||||
| 22 July | Brisbane Broncos | 10 – 12 | Penrith Panthers | Suncorp Stadium | View |
| 23 July | Canberra Raiders | 24 – 14 | Warriors | GIO Stadium | View |
| 23 July | Gold Coast Titans | 52 – 10 | Parramatta Eels | Pizzey Park | View |
| 23 July | Melbourne Storm | 32 – 44 | Sydney Roosters | Sunshine Coast Stadium | View |
| 23 July | North Queensland Cowboys | 44 – 12 | Canterbury Bulldogs | Jack Manski Oval | View |
| 24 July | Cronulla Sharks | 24 – 18 | Newcastle Knights | S. Cross Group Stadium | View |
| 24 July | St George Illawarra Dragons | 16 – 36 | Wests Tigers | ANZ Stadium | View |
| 25 July | South Sydney Rabbitohs | 44 – 40 | Manly Sea Eagles | Allianz Stadium | View |
| Round 21 | |||||
| 28 July | Sydney Roosters | 38 – 24 | Brisbane Broncos | Allianz Stadium | View |
| 29 July | Canterbury Bulldogs | 52 – 18 | St George Illawarra Dragons | ANZ Stadium | View |
| 30 July | Warriors | 30 – 28 | Penrith Panthers | Mt Smart Stadium | View |
| 30 July | Parramatta Eels | 25 – 18 | Wests Tigers | ANZ Stadium | View |
| 30 July | North Queensland Cowboys | 38 – 14 | Melbourne Storm | 1300SMILES Stadium | View |
| 31 July | South Sydney Rabbitohs | 10 – 48 | Canberra Raiders | ANZ Stadium | View |
| 31 July | Manly Sea Eagles | 52 – 22 | Newcastle Knights | Brookvale Oval | View |
| 1 August | Gold Coast Titans | 28 – 34 | Cronulla Sharks | Cbus Super Stadium | View |
| Round 22 | |||||
| 4 August | St George Illawarra Dragons | 12 – 16 | Brisbane Broncos | WIN Stadium | View |
| 5 August | Parramatta Eels | 24 – 10 | Manly Sea Eagles | Pirtek Stadium | View |
| 6 August | Newcastle Knights | 24 – 34 | Canterbury Bulldogs | Hunter Stadium | View |
| 6 August | Melbourne Storm | 48 – 14 | South Sydney Rabbitohs | Sunshine Coast Stadium | View |
| 6 August | Cronulla Sharks | 12 – 18 | Canberra Raiders | S. Cross Group Stadium | View |
| 7 August | Gold Coast Titans | 22 – 20 | Warriors | Cbus Super Stadium | View |
| 7 August | Wests Tigers | 36 – 12 | North Queensland Cowboys | Leichhardt Oval | View |
| 8 August | Penrith Panthers | 40 – 22 | Sydney Roosters | Pepper Stadium | View |
| Round 23 | |||||
| 11 August | Canterbury Bulldogs | 56 – 0 | Manly Sea Eagles | ANZ Stadium | View |
| 12 August | Brisbane Broncos | 34 – 32 | Parramatta Eels | Suncorp Stadium | View |
| 13 August | Wests Tigers | 34 – 36 | Gold Coast Titans | Campbelltown Stadium | View |
| 13 August | St George Illawarra Dragons | 32 – 34 | Cronulla Sharks | UOW Jubilee Oval | View |
| 13 August | Canberra Raiders | 26 – 34 | Melbourne Storm | Seiffert Oval | View |
| 13 August | Warriors | 20 – 30 | South Sydney Rabbitohs | Mt Smart Stadium | View |
| 14 August | Newcastle Knights | 32 – 24 | Penrith Panthers | Hunter Stadium | View |
| 14 August | Sydney Roosters | 42 – 24 | North Queensland Cowboys | Allianz Stadium | View |
| Round 24 | |||||
| 18 August | Brisbane Broncos | 28 – 30 | Canterbury Bulldogs | Suncorp Stadium | View |
| 19 August | Penrith Panthers | 14 – 22 | Wests Tigers | Pepper Stadium | View |
| 20 August | Newcastle Knights | 36 – 24 | Gold Coast Titans | Hunter Stadium | View |
| 20 August | Manly Sea Eagles | 28 – 28 | Melbourne Storm | Brookvale Oval | View |
| 20 August | North Queensland Cowboys | 34 – 0 | Warriors | 1300SMILES Stadium | View |
| 21 August | Canberra Raiders | 28 – 12 | Parramatta Eels | GIO Stadium | View |
| 21 August | Sydney Roosters | 24 – 25 | St George Illawarra Dragons | Allianz Stadium | View |
| 22 August | South Sydney Rabbitohs | 16 – 18 | Cronulla Sharks | ANZ Stadium | View |
| Round 25 | |||||
| 25 August | Canterbury Bulldogs | 14 – 32 | North Queensland Cowboys | Belmore Sports Ground | View |
| 27 August | Manly Sea Eagles | 22 – 56 | Canberra Raiders | Brookvale Oval | View |
| 27 August | Melbourne Storm | 24 – 68 | Brisbane Broncos | Sunshine Coast Stadium | View |
| 27 August | Gold Coast Titans | 26 – 28 | Penrith Panthers | Cbus Super Stadium | View |
| 27 August | Cronulla Sharks | 34 – 28 | Sydney Roosters | S. Cross Group Stadium | View |
| 28 August | Warriors | 24 – 24 | Wests Tigers | Mt Smart Stadium | View |
| 28 August | Newcastle Knights | 32 – 12 | South Sydney Rabbitohs | Hunter Stadium | View |
| 29 August | Parramatta Eels | 10 – 32 | St George Illawarra Dragons | Pirtek Stadium | View |
| Round 26 | |||||
| 1 September | Brisbane Broncos | 22 – 22 | Sydney Roosters | Suncorp Stadium | View |
| 2 September | Canterbury Bulldogs | 44 – 20 | South Sydney Rabbitohs | ANZ Stadium | View |
| 3 September | St George Illawarra Dragons | 26 – 16 | Newcastle Knights | UOW Jubilee Oval | View |
| 3 September | Melbourne Storm | 30 – 36 | Cronulla Sharks | Sunshine Coast Stadium | View |
| 3 September | North Queensland Cowboys | 42 – 22 | Gold Coast Titans | 1300SMILES Stadium | View |
| 4 September | Wests Tigers | 28 – 28 | Canberra Raiders | Leichhardt Oval | View |
| 4 September | Warriors | 18 – 32 | Parramatta Eels | Mt Smart Stadium | View |
| 4 September | Penrith Panthers | 47 – 14 | Manly Sea Eagles | Pepper Stadium | View |